Jim Prell


Jim Prell attended college at Washington University in Saint Louis, where he obtained a B.A. in 2005 in chemistry, mathematics, and German, with minors in music and religious studies. He attended graduate school at the University of California, Berkeley (research adviser: Evan R. Williams) and received a Ph.D. in Chemistry in 2011. His research focused on the structure and reactivity of non-covalently bound ions, including ion-biomolecule complexes and extensively hydrated ions. From January 2011 through July 2014, he worked as a post-doctoral scholar at the University of California, Berkeley (research adviser: Stephen R. Leone), studying attosecond-resolved photoelectron imaging of plasmons. He joined the University of Oregon Department of Chemistry and Biochemistry in August 2014, and he is a member of the Materials Science Institute and an associate member of the Center for Optical, Molecular, and Quantum Science. Jim is the faculty sponsor for UO’s chapter of the Society for the Advancement of Chicanos/Hispanics and Native Americans in Science. Outside of physical and bioanalytical chemistry, Jim’s interests include classical music performance and composition, running, biking, coffee, cooking, and foreign languages.


  1. Zürch, M.; Chang, H.-T.; Kraus, P. M.; Cushing, S. K.; Borja, L. J.; Gandman, A.; Kaplan, C. J.; Oh, M. H.; Prell, J. S.; Prendergast, D.; Pemmaraju, C. D.; Neumark, D. M.; Leone, S. R. Carrier Trapping and Thermalization in Silicon-Germanium Alloy Probed by Attosecond XUV Transient Absorption Spectroscopy. Structural Dynamics 2017, 4, 044029 DOI: 10.1063/1.4985056
  2. Zürch, M.; Chang, H.-T.; Borja, L.J.; Kraus, P.M.; Cushing, S.K.; Gandman, A.; Kaplan, C.J.; Oh, M.H.; Prell, J.S.; Prendergast, D.; Pemmaraju, C.D.; Neumark, D.M.; Leone, S.R. Direct and Simultaneous Observation of Ultrafast Electron and Hole Dynamics in Germanium. Nature Comm. 2017, in press.
  3. Hartle, M.D.; Tillotson, M.R.; Prell, J.S.; Pluth, M.D. Spectroscopic Investigation of the Reaction of Metallo-Protoporphyrins with Hydrogen Sulfide. J. Inorg. Bio. 2017, in press DOI: 10.1016/j.jinorgbio.2017.04.021
  4. Donor, M.T.; Ewing, S.A.; Zenaidee, M.A.; Donald, W.A.; Prell, J.S.* Extended Protein Ions are Formed by the Chain Ejection Model in Chemical Supercharging Electrospray Ionization. Anal. Chem. 2017, DOI: 10.1021/acs.analchem.7b00673
  5. Ewing, S.A.; Donor, M.T.; Wilson, J.W.; Prell, J.S.* Collidoscope: An Improved Tool for Computing Collisional Cross Sections with the Trajectory Method. J. Am. Soc. Mass Spectrom.2017 DOI: 10.1007/s13361-017-1594-2 [Focus Issue: Emerging Investigators]
  6. Wheeler, L.C.; Donor, M.T.; Prell, J.S.; Harms, M. J. Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. PLOS ONE 2016 DOI: 10.1371/journal.pone.0164740
  7. Cleary, S.P.; Thompson, A.M.; Prell, J.S.* Fourier Analysis Method for Analyzing Highly Congested Mass Spectra of Ion Populations with Repeated Subunits. Anal. Chem. 2016, 88, 6205-6213 DOI: 10.1021/acs.analchem.6b01088
  8. Taber, B.; Kislitsyn, D.A.; Gervasi, C.F.; Mills, J.M.; Rosenfield, A.E.; Zhang, L.; Mannsfeld, S.C.B.; Prell, J.S.; Briseno, A.L.; Nazin, G.V. Real-Space Visualization of Conformation-Dependent Oligothiophene Electronic Structure. J. Chem. Phys. 2016, 144, 194703 DOI: 10.1063/1.4949765
  9. Borja, L.J.; Zürch, M.; Pemmaraju, C.D.; Schultze, M.; Ramasesha, K.; Gandman, A.; Prell, J.S.; Prendergast, D.; Neumark, D.M.; Leone, S.R. Extreme Ultraviolet Transient Absorption of Solids from Femtosecond to Attosecond Timescales. J. Opt. Soc. Am. B, 2016 (invited review). DOI: 10.1364/JOSAB.33.000C57
  10. Hartle, M.D.; Prell, J.S.; Pluth, M.D. Spectroscopic Investigations into the Binding of Hydrogen Sulfide to Synthetic Picket-Fence Porphyrins. J. Chem. Soc., Dalton Trans. 2016, 45, 4843-4853. DOI: 10.1039/C5DT04563K
  11. Kislitsyn, D.A.; Taber, B.; Gervasi, C.F.; Zhang, L.; Mannsfeld, S.C.B; Prell, J.S.; Briseno, A.; Nazin, G.Y. Oligothiophene Wires: Impact of Torsional Conformation on the Electron Structure. Phys. Chem. Chem. Phys. 2016, 18, 4842-4849. DOI: 10.1039/C5CP07092A
  12. Schultze, M.; Ramasesha, K.; Pemmaraju, C.D.; Sato, S.A.; Whitmore, D.; Gandman, A.; Prell, J.S.; Borja, L.; Prendergast, D.; Yabana, K.; Neumark, D.M.; Leone, S.R. Attosecond Band Gap Dynamics in Silicon. Science 2014, 346, 1348-1352. DOI: 10.1126/science.1260311
  13. Gomez, L.F.; Ferguson, K.R.; Cryan, J.P.; Bacellar, C.; Tanyag, R.M.P.; Jones, C.; Schorb, S.; Anielski, D.; Belkacem, A.; Bernando, C.; Boll, R.; Bozek, J.; Carron, S.; Chen, G.; Delmas, T.; Englert, L.; Epp, S.W.; Erk, B.; Foucar, L.; Hartmann, R.; Hexemer, A.; Huth, M.; Kwok, J.; Leone, S.R.; Ma, J.H.S.; Maia, F.R.N.C.; Malmerberg, E.; Marchesini, S.; Neumark, D.M.; Poon, B.; Prell, J.; Rolles, D.; Rudek, B.; Rudenko, A.; Seifrid, M.; Siefermann, K.R.; Sturm, F.P.; Swiggers, M.; Ulrich, J.; Weise, F.; Zwart, P.; Bostedt, C.; Gessner, O.; Vilesov, A.F. Shapes and Vorticities of Superfluid Helium Droplets. Science2014, 345, 906-909. DOI: 10.1126/science.1252395
  14. Prell, J.S.; Borja, L.J.; Neumark, D.M.; Leone, S.R. Simulation of Attosecond-Resolved Imaging of the Plasmon Electric Field in Metallic Nanoparticles. Ann. Phys.—Berlin 2013, 525, 151-161. DOI: 10.1002/andp.201200201
  15. Nagel, P.M.; Robinson, J.S.; Harteneck, B.; Pfeifer, T.; Abel, M.J.; Prell, J.S.; Neumark, D.M.; Kaindl, R.A.; Leone, S.R. Surface Plasmon Assisted Electron Acceleration in Photoemission from Gold Nanopillars. Chem. Phys. 2013, 414, 106-111. DOI: 10.1016/j.chemphys.2012.03.013
  16. Chang, T.M.; Prell, J.S.; Warrick, E.R.; Williams, E.R. Where’s the Charge? Protonation Sites in Gaseous Ions Change with Hydration. J. Am. Chem. Soc. 2012, 134, 15805-15813. DOI: 10.1021/ja304929h
  17. Sterling, H.J; Prell, J.S.; Cassou, C.A.; Williams, E.R. Protein Conformation and Supercharging with DMSO from Aqueous Solution. J. Am. Soc. Mass Spectrom. 2011, 22, 1178–1186. DOI: 10.1007/s13361-011-0116-x
  18. Prell, J.S.; Chang, T.M.; Biles, J.A.; Berden, G.; Oomens, J.; Williams, E.R. Isomer Population Analysis of Gaseous Ions from Infrared Multiple Photon Dissociation Spectroscopy. J. Phys. Chem. A 2011, 115, 2745–2751. DOI: 10.1021/jp2004166
  19. Prell, J.S.; O’Brien, J.T.; Williams, E.R. Structural and Electric Field Effects of Ions in Aqueous Nanodrops. J. Am. Chem. Soc. 2011, 133, 4810–4818. DOI: 10.1021/ja108341t
  20. Prell, J.S.; Correra, T.C.; Chang, T.M.; Biles, J.A.; Williams, E.R. Entropy Drives a Water Molecule from the C- to N-Terminus on Protonated Proline. J. Am. Chem. Soc. 2010, 132, 14733–14735. DOI: 10.1021/ja106167d
  21. O’Brien, J.T.; Prell, J.S.; Berden, G.; Oomens, J.; Williams, E.R. Effects of Anions on the Zwitterion Stability of Glu, His, and Arg Investigated by IRMPD Spectroscopy and Theory. Int. J. Mass Spectrom. 2010, 297, 116–123. DOI: 10.1016/j.ijms.2010.07.003
  22. O’Brien, J.T.; Prell, J.S.; Williams, E.R. Sulfate Ion Patterns Water at Long Distance. J. Am. Chem. Soc. 2010, 132, 8248–8249. DOI: 10.1021/ja1024113
  23. Prell, J.S.; Chang, T.M.; O’Brien, J.T.; Williams, E.R. Hydration Isomers of Protonated Phenylalanine and Derivatives: Relative Stabilities from Infrared Photodissociation. J. Am. Chem. Soc. 2010132, 7811–7819. DOI: 10.1021/ja102765w
  24. Prell, J.S.; O’Brien, J.T.; Williams, E.R. IRPD Spectroscopy and Ensemble Measurements: Effects of Different Data Acquisition and Analysis Methods. J. Am. Soc. Mass Spectrom. 2010, 21, 800–809. DOI: 10.1016/j.jasms.2010.01.010
  25. Prell, J.S.; Flick, T.G.; Oomens, J.; Berden, G.; Williams, E.R. Coordination of Trivalent Metal Cations to Peptides: Results from IRMPD Spectroscopy and Theory. J. Phys. Chem. A 2010, 114, 854–860. DOI: 10.1021/jp909366a
  26. Bush, M.F.; O’Brien, J.T.; Prell, J.S.; Wu, C.; Saykally, R.J.; Williams, E. R. Hydration of Alkaline Earth Metal Dications: Effects of Metal Ion Size Determined Using Infrared Action Spectroscopy. J. Am. Chem. Soc. 2009, 131, 13270–13277. DOI: 10.1021/ja901011x
  27. Donald, W.A.; Leib, R.D.; Demireva, M.; O’Brien, J.T.; Prell, J.S.; Williams, E.R. Directly Relating Reduction Energies of Gaseous Eu(H2O)n3+, n = 55-140, to Aqueous Solutions: The Absolute SHE Potential and Real Proton Solvation Energy. J. Am. Chem. Soc. 2009, 131, 13328–13337. DOI: 10.1021/ja902815v
  28. Prell, J.S.; O’Brien, J.T.; Steill, J.D.; Oomens, J.; Williams, E.R. Structures of Protonated Dipeptides: The Role of Arginine in Stabilizing Salt Bridges. J. Am. Chem. Soc. 2009131, 11442–11449. DOI: 10.1021/ja901870d
  29. Prell, J.S.; Williams, E.R. Structures of Thermal, Mass-Selected Water Clusters Probed with Hydrophobic Ion Tags and Infrared Photodissociation Spectroscopy. J. Am. Chem. Soc. 2009131, 4110–4119. DOI: 10.1021/ja809414a
  30. O’Brien, J.T.; Prell, J.S.; Steill, J.D.; Oomens, J.; Williams, E.R. Changes in Binding Motif of Protonated Heterodimers Containing Valine Investigated Using IRMPD Spectroscopy between 800 and 3700 cm−1 and Theory. J. Am. Chem. Soc. 2009131, 3905-3912. DOI: 10.1021/ja809928h
  31. Prell, J.S.; Demireva, M.; Williams, E.R. Role of Sequence in Salt-Bridge Formation for Alkali Metal Cationized GlyArg and ArgGly Investigated with IRMPD Spectroscopy and Theory. J. Am. Chem. Soc. 2009131, 1232–1242. DOI: 10.1021/ja808177z
  32. O’Brien, J.T.; Prell, J.S.; Steill, J.D.; Oomens, J.; Williams, E.R. Interactions of Mono- and Divalent Metal Cations with Aspartic and Glutamic Acid Investigated with Infrared Photodissociation Spectroscopy and Theory. J. Phys. Chem. A 2008112, 10823–10830. DOI: 10.1021/jp805787e
  33. Prell, J.S.; O’Brien, J.T.; Holm, A.I.S.; Leib, R.D.; Donald, W.A.; Williams, E.R. Electron Capture Dissociation by a Hydrated Gaseous Peptide: Effects of Water on Fragmentation and Molecular Survival. J. Am. Chem. Soc. 2008130, 12680–12689. DOI: 10.1021/ja8022434
  34. O’Brien, J.T.; Prell, J.S.; Holm, A.I.S.; Williams, E.R. Effects of Electron Kinetic Energy and Ion-Electron Inelastic Collisions in Electron Capture Dissociation Measured Using Ion Nanocalorimetry. J. Am. Soc. Mass Spectrom. 200819, 772–779. DOI: 10.1016/j.jasms.2008.02.010
  35. Bush, M.F.; Prell, J.S.; Saykally, R.J.; Williams, E.R. One Water Molecule Stabilizes the Cationized Arginine Zwitterion. J. Am. Chem. Soc. 2007129, 13544–13553. DOI: 10.1021/ja073796b
  36. Bush, M.F.; O’Brien, J.T.; Prell, J.S.; Saykally, R.J.; Williams, E.R. Infrared Spectroscopy of Cationized Arginine in the Gas Phase: Direct Evidence for the Transition from Nonzwitterionic to Zwitterionic Structure. J. Am. Chem. Soc. 2007129, 1612–1622. DOI: 10.1021/ja066335j
  37. Gaspar, P.P.; Liu, X.P.; Ivanova, D.; Read, D.; Prell, J.S.; Gross, M.L. Four Valence-Electron Reactive Intermediates and the Philicity of Charged Carbene Analogs. Modern Aspects of Main Group Chemistry 2006917, 52–65.


Recent Presentations

“Native Ion Mobility-Mass Spectrometry of Partially Unfolded Proteins” (invited talk). Federation of Analytical Chemistry and Spectroscopic Societies “SCIentific eXchange” Conference, Minneapolis, MN, 20 September 2016.

“Native Mass Spectrometry and Ion Mobility Analysis of Membrane Proteins and Assemblies” (invited talk). American Chemical Society National Meeting, Philadelphia, PA, 22 August 2016.

“Unfolding Pathways of Anthrax Toxin Proteins Investigated with Native Mass Spectrometry and Ion Mobility” (poster). American Society for Mass Spectrometry Annual Conference, San Antonio, TX, 9 June 2016.

“Fourier Transform Algorithm for Analysis of Mass Spectra for Heterogeneous Ions with Repeated Subunits” (poster). American Society for Mass Spectrometry Annual Conference, San Antonio, TX, 7 June 2016.

“Fourier Deconvolution for Mass Spectra of Large Assemblies with Repeated Subunits” (mini-talk and poster). American Society for Mass Spectrometry Asilomar Conference on Native Mass Spectrometry for Structural Biology, Pacific Grove, CA, 19 September 2015.

“New Methods for Mass Spectrometry of Nanoscale Biological Assemblies” (invited talk). University of Oregon Center for Optical, Molecular, and Quantum Science Annual Retreat, McMinnville, OR, 15 September 2015.